Biological and therapeutic implications of sex hormone-related gene clustering in testicular cancer

Table 1 Characteristic of the investigated cohorts of testicular cancer patients

Variable^a	TCGA	GSE99420	Significance^b	Effect size^b
Age	31 [IQR: 26—37] range: 14—67 complete: n = 133
Race/Ethnicity	Asian: 3.1% (4) Black or African American: 4.7% (6) White: 92% (118) complete: n = 128
Tumor stage	I: 84% (102) II: 9% (11) III: 7.4% (9) complete: n = 122
Metastasis stage	M0: 97% (114) M1: 3.4% (4) complete: n = 118
Node stage	N0: 79% (46) N1: 17% (10) N2: 3.4% (2) complete: n = 58
IGCCCG	good: 74% (32) intermediate: 21% (9) poor: 4.7% (2) complete: n = 43
Histology	seminoma: 43% (62) NSGCT: 57% (82) complete: n = 144	seminoma: 50% (30) NSGCT: 50% (30) complete: n = 60	ns (p = 0.45)	V = 0.064
Histology, ICD-O	seminoma: 49% (65) germinal mixed histology: 20% (27) benign teratoma: 3.8% (5) embryonal carcinoma: 20% (27) malignant teratoma: 2.3% (3) teratocarcinoma: 1.5% (2) yolk sac cancer: 3% (4) complete: n = 133
Marker status	S0: 36% (43) S1: 31% (37) S2: 29% (34) S3: 4.2% (5) complete: n = 119
Neoadjuvant therapy	no: 100% (133) complete: n = 133
Radiation	16% (21) complete: n = 130
Follow-up, months	1300 [IQR: 680—2700] range: 3—7400 complete: n = 133
Death	3% (4) complete: n = 133
Relapse	25% (33) complete: n = 133	50% (30) complete: n = 60	p = 0.002	V = 0.25
Progression	26% (34) complete: n = 133

^aIGCCCG International Germ Cell Cancer Collaborative Group risk strata, ICD-0 International classification of diseases for oncology, histological subtype
^bNumeric variables: Kruskal–Wallis test with η² effect size statistic. Categorical variables: χ² test with Cramer‘s V effect size statistic. P values corrected for multiple testing with the false discovery rate method
Numeric variables are presented as medians with interquartile ranges and ranges. Qualitative variables are shown as percentages and counts of the categories within the complete observation set

ISSN: 2051-4190